Sickle cell anaemia is a genetic blood disorder that affects the shape and function of red blood cells. Instead of being round and flexible, the red blood cells become crescent or sickle-shaped. These irregularly shaped cells can block blood flow, break down prematurely, and cause various health complications such as pain episodes, infections, organ damage, and fatigue.
Understanding its causes, symptoms, and treatment options is essential for patients and families seeking the best possible care.
What Causes Sickle Cell Anaemia?
Sickle cell anaemia occurs due to a mutation in the gene that produces haemoglobin, the protein responsible for carrying oxygen throughout the body. If a child inherits the defective gene from both parents, they develop sickle cell anaemia.
Common Symptoms of Sickle Cell Anaemia
Patients with sickle cell anaemia may experience:
- Episodes of pain (often in bones, chest, or abdomen)
- Swelling in hands and feet
- Frequent infections due to a weakened spleen
- Fatigue or anaemia
- Vision problems caused by blocked blood vessels in the eyes
These symptoms may vary in severity from person to person.
Available Treatments for Sickle Cell Anaemia
While sickle cell anaemia currently has no universal cure, several treatments can help manage the condition, reduce complications, and improve quality of life.
1. Medications
- Hydroxyurea: Helps reduce painful episodes and the need for blood transfusions.
- Voxelotor: Improves haemoglobin levels and reduces red blood cell breakdown.
- Crizanlizumab: Reduces the frequency of pain crises.
- : Lower the risk of infections.
2. Blood Transfusions
Regular transfusions provide healthy red blood cells, improving oxygen delivery and reducing complications such as stroke.
3. Bone Marrow or Stem Cell Transplant
Currently, this is the only potential cure for sickle cell anaemia. It involves replacing the patient's bone marrow with healthy stem cells from a donor. However, it is only suitable for certain patients and comes with risks.
4. Lifestyle & Supportive Care
- Staying hydrated
- Avoiding extreme temperatures
- Regular health check-ups
- Pain management with prescribed medications
- Nutritional support and folic acid supplements
Living with Sickle Cell Anaemia
With proper care and timely treatment, patients can lead fulfilling lives. Regular monitoring, early treatment of complications, and healthy lifestyle practices can significantly improve life expectancy and well-being.
Cost of Treatment in India
Many patients and families are also concerned about the affordability of care. The sickle cell anaemia treatment cost in India depends on the type of treatment chosen (medications, transfusions, or bone marrow transplant), hospital facilities, and the patient's overall health condition. Consulting a haematologist can provide a clear estimate based on individual needs.
Final Thoughts
Sickle cell anaemia is a challenging condition, but advances in medicine and supportive care have made it possible to manage symptoms effectively and live longer, healthier lives. If you or a loved one has sickle cell anaemia, seeking timely medical advice, staying informed about treatment options, and maintaining a healthy lifestyle can make a big difference.
